Cross-Sphere

The Author: A group of hunters known as The Children of Athanasius have identified a powerful relic in an attempt to gain the upper hand in destroying the non-supernatural.

Vampire-Centric

The Children Of Athanasius: Prince Winder has launched an investigation into a group of chillingly-informed vampire hunters announced themselves to the Bay area with an execution film in the guise of a supernatural thriller movie.
Finding The Iron Shields: A group of vampire hunters have reportedly kidnapped the Sabbat pack, The Iron Shields, and the sects each want to track them down -- whether to recover their brethren or leverage the missing vampires as a lead to exterminate the hunters.

Sutro Baths: The Technocratic Union has taken over a node previously occupied by a mysterious, violent monster.

Drug Syndicates: San Francisco's opiate crisis has been worsened not only with fentanyl, but the introduction of untraceable ghost guns.
SF Open Heart: A homeless advocacy group is trying to make a dent in the drug crisis.